AKT1 and primary effusion lymphoma: Additionally, SFN was found to decrease sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells by possibly inhibiting the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and AKT, which are crucial pro-oncogenic pathways involved in cell proliferation, migration, invasion, and cell survival (31).