CHD1 and Familial prostate cancer: Several preclinical studies using prostate cancer cell lines, PDX models, and GEM models demonstrated that CHD1 loss leads to hypersensitivity to ionizing radiation (IR), PARP inhibition, and DNA-damaging agents, such as mitomycin C, carboplatin, irinotecan, and camptothecin (21, 24, 88–90).