COMMD6 was discovered to be highly expressed in 20 types of tumors, such as colon cancer and brain lower grade glioma (LGG), and to be poorly expressed in 11 other types of tumors, including adrenocortical carcinoma (ACC) and pheochromocytoma. This evidence concerns the gene COMMD6 and hereditary pheochromocytoma-paraganglioma.