COMMD7 is highly expressed in PDAC; COMMD7 is positively correlated with PDAC histological differentiation, lymph node metastasis and TMN stage. Inhibition of COMMD7 may inhibit tumor proliferation and invasion by down-regulating cyclin D1, inhibiting MMP-2 secretion, and activating ERK1/2 and apoptosis (86). This evidence concerns the gene MMP2 and neoplasm.