HIF1A and neoplasm: COMMD1 inhibits Nf-κb and HIF-1 in H460 cells, and plays an anti-inflammatory, anti-tumor and anti-angiogenesis role (68, 69). COMMD1 is highly expressed in NSCLC cells and repairs DNA DSBs. Up-regulation of COMMD1 is associated with poor prognosis in patients with NSCLC (17).