Non-VA triggered CS patients presented with higher initial Nt-proBNP and CRP (respectively, 10,763 vs. 5,360 pg/ml, p < 0.01 and 29 vs. 15 mg/L, p < 0.01), higher creatinin and poorer prothrombin time at 24 h (respectively, 129 vs. 106 μmol/L, p = 0.04 and 60 vs. 70%, p < 0.01). The gene discussed is CRP; the disease is Cowden syndrome 1.