Moreover, acute and long-term overexpression of liver-specific RBP4 in murine increase circulating RBP4 levels to the same level observed in glucose intolerance and insulin resistance conditions; however, it did not disturb the glucose homeostasis suggesting that liver-secreted RBP4 is not associated with the development of glucose intolerance and insulin resistance [34]. The gene discussed is RBP4; the disease is Glucose intolerance.