Moreover, despite the absence of histological features of high‐grade malignancy (necrosis, angiogenesis), an IDHwt glioma can still be classified as GBM when EGFR amplification, the combination of gain of chromosome 7 and loss of chromosome 10 (7+/10‐), and TERT promoter mutation are present. The gene discussed is EGFR; the disease is glioma.