Studies using an AML xenograft model in mice have identified that EVs from human AML cells transport human transcripts such as FLT3 and CXCR4 to murine hematopoietic stem progenitor cells (HSPCs) in the bone marrow and how AML EVs carrying miRNAs regulate function of residual HSPCs by targeting the critical transcription factor c‐Myb, leading to progression of AML (Abdelhamed et al., 2021; Hornick et al., 2016). Here, FLT3 is linked to acute myeloid leukemia.