Evidence showed that RNAseq analysis of EVs isolated using EVHB‐Chip functionalized with an antibody cocktail against EGFRvIII, Cetuximab, PDPN and PDGFR led to the identification of at least 100 differentially expressed genes in EVs isolated from glioblastoma patients compared with healthy controls, and allowed discrimination between glioblastoma patients with progressive versus pseudoprogressive disease states based on EV‐RNA signatures. Here, PDPN is linked to glioblastoma.