EHBP1L1 may play a role in vesicular trafficking via interacting with the Rab family, including Rab8 and Rab10.[23, 24] Our previous study reported that EHBP1L1 is correlated with poor prognosis in RCC.[25] In the present study, we identify EHBP1L1 as a key regulator of IFN‐γ/JAK1/STAT1/PD‐L1 signaling, and we demonstrate that EHBP1L1 interacts with JAK1 and increases JAK1 stability. This evidence concerns the gene STAT1 and renal cell carcinoma.