Concordantly, a recent report using a gain‐of‐function approach showed that the TEAD‐binding domain of YAP1 is essential for cyst formation of human blastoids.[27] Here, we further demonstrated that the mutated YAP1 could functionally reduce the attachment potential of BAP‐EB onto endometrial cells likely due to a defective TE differentiation. This evidence concerns the gene YAP1 and cyst.