Some studies have previously shown that these cancer cell lines have very low or no DR4 expression.54,55 Furthermore, it has been reported that TRAIL-induced apoptosis is preferentially mediated via DR5 in AsPC-1 and Panc1.54,55 These results suggest that DR4 is not contributing to TRAIL-induced apoptosis, and nimesulide does not affect the DR4 expression levels in all these cell lines. This evidence concerns the gene TNFSF10 and cancer.