Furthermore, prospective studies also showed the association of skipping breakfast with weight gain(7), abdominal obesity(8,9), obesity(8), metabolic syndrome(8), type 2 diabetes(10,11), dyslipidaemia(9), higher fasting insulin(9), risk of CVD(12,13) and total mortality(14). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.