In contrast to liver-specific BDH1 KO mice that still increase ketone body concentrations in response to fasting (39) and liver-specific PPARa KO mice that have lower but inducible ketone bodies in response during sepsis (40), HmgclAlb-Cre mice also fail to induce ketogenesis in response to fasting (Fig. 1I) and they have lower blood glucose levels under fasting conditions (Fig. 1J). Here, PPARA is linked to Sepsis.