However, when we gave HmgclS100a8-Cre mice intraperitoneal (ip) injections of monosodium urate crystals, the causative agent of gout and potent neutrophil stimulus, HMGCL-deficient neutrophils had similar migration into the peritoneal cavity, but there was an overall lower inflammatory response based on Il1b and Tnfa gene expression (Figs. 3, G–J and S1). Here, IL1B is linked to gout.