The multifactor analysis confirmed that high SPATS2L was an independent poor prognostic factor for OS, EFS, and RFS in AML for the first time Increased SPATS2L expression had stronger prognostic significance and a higher HR for RFS in AML patients, indicating that SPTATS2L might be a better predictor of relapse. Here, SPATS2L is linked to acute myeloid leukemia.