In line, higher FBXO22 mRNA and protein levels were detected in MLLr AML cell lines (Molm13, THP-1 and MV4-11) than non-MLLr cell lines (Kasumi-1, HL-60 and U937) (Additional file 2: Fig. S1H, I). Here, FBXO22 is linked to acute myeloid leukemia.