FBXO22 and acute myeloid leukemia: Similarly, the deficiency of Fbxo22 in Scl-Cre;Fbxo22fl/fl mice also significantly inhibited AML development during secondary transplantation (Additional file 5: Fig. S4A–D), and had markedly increased survival time in both secondary and tertiary transplantation (Additional file 5: Fig. S4E, F).