In addition, GFP+ AML cells from Mx1-Cre–;Fbxo22fl/fl and Mx1-Cre+;Fbxo22fl/fl mice were transplanted into lethally irradiated recipients, followed treatment with pIpC from day 7 to induce Fbxo22 deletion (Additional file 5: Fig. S4H). Here, FBXO22 is linked to acute myeloid leukemia.