FBXO22 and acute myeloid leukemia: To determine the potential role in primary AML, we knocked down FBXO22 in BM mononuclear cells from 3# patient, who had higher FBXO22 protein (Fig. 1B), by two pairs of short hairpin RNAs (shRNAs) specifically against FBXO22 with the scramble shRNA (shNC) as a control.