FBXO22 and acute myeloid leukemia: We also analyzed FBXO22 protein levels in mononuclear cells from BM of 15 cases of various morphologic subtypes of primary human AML together with samples from 9 cases of non-leukemic individuals as control (Additional file 1: Table S1), and results revealed that FBXO22 proteins were also aberrantly elevated to various degrees in AML patients compared to control individuals (Fig. 1B).