During the GH-producing PitNET transcriptome analysis we were able to identify 1595 DEGs that distinguished this group from non-functional PitNET, the expected result was that growth hormone related pathways were upregulated in GH-producing group, but alongside that we also detected other candidates among these only 41 have been mentioned in transcriptomic studies of PitNETs, therefore, there are distinct patterns that characterise GH-producing PitNETs that could be used for better understanding of tumour biology and development of management strategies [1]. This evidence concerns the gene GH1 and neoplasm.