To date, the precise pathogenesis of PD remains unclear; the pathological hallmark of PD involves the progressive dysfunction of the nigrostriatal pathway, ultimately leading to loss of dopaminergic innervation in the striatum along with widespread intracellular α-Synuclein (α-Syn) aggregates in the substantia nigra pars compacta (SNc) [2].Although there are several drugs to treat symptoms in patients with PD, these fail to prevent disease progression. The gene discussed is SNCA; the disease is Parkinson disease.