Investigating the 332 upregulated genes in LM in another scRNA-Seq data from the T cell population of NSCLC using CellphoneDB, we predicted ligands (CCL3L3, CCL5, CCL3, and HLA-G) and receptors (CCR1 and LILRB2) communications among effectors, exhausted, pre-exhausted, and naive CD8+ T cells (Fig. 5E). The gene discussed is CCL3L3; the disease is non-small cell lung carcinoma.