Furthermore, we emphasized the importance of the genera Faecalibacterium and Bifidobacterium as two potentially protective taxa in IBS individuals. Faecalibacterium prausnitzii is a butyrate-producing microbe with anti-inflammation efficacy by mediating the expression of interleukin-17 [25], and it can also enhance the integrity of gastrointestinal barriers [26, 27]. This evidence concerns the gene IL17A and irritable bowel syndrome.