No significant difference was found regarding preoperative pituitary insufficiency, intraoperative CSF space opening, new postoperative pituitary insufficiency or diabetes insipidus/SIADH, expression of histological markers such as Ki67, p53, mitotic rate and tumor recurrence were observed between cystic and non-cystic SCAs by patients who underwent first surgery. The gene discussed is TP53; the disease is Central diabetes insipidus.