Considering the role of MDA asa metabolite of oxidative stress and SOD as an antioxidant enzyme, increased MDAlevel and decreased SOD activity indicated the state of high oxidative stress, whichwas the highest in the HHcy + SHR group, then the SHR group and the HHcy group.Therefore, HHcy combined with hypertension significantly promoted the level ofoxidative stress in rat arterial blood. This evidence concerns the gene SOD1 and Hypertension.