In order to explore the dominant mechanism of oxidative stress and/orinflammation on HHcy aggravating the arterial damage in hypertension, we specificallyobserved the mRNA and protein expression levels of oxidative stress molecules (Nox2 andNox4) and inflammatory factors (TNF-a and IL-6) in the HHcy group and the SHR group. Here, TNF is linked to hypertensive disorder.