TNF and hypertensive disorder: The study found that NF-κB molecules areclosely related to the inflammation response12, and the activation of NF-κB can induceinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6(IL-6)13.However, it is unclear whether the inflammation reaction is the leading cause of thearterial injury in hypertension associated with HHcy, and whether HHcy aggravates thearterial damage of hypertension through Akt1/NF-κB signaling pathways.