Our research suggests that OLE can provide potent neuro-survival effect against the key factors of neurodegeneration in PD, like oxidative stress, α-synuclein upregulation, altered Ca2+ level, mitochondrial dysfunction, downregulation of neurotrophic factors and apoptosis by regulating BDNF/Akt/CREB signalling. This evidence concerns the gene CREB1 and Parkinson disease.