We observed that FBXO44 OE increased the growth of AEG xenograft tumors by 2.54-fold (P = 0.004), whereas FBXO44 KD suppressed tumor growth by 67.17% (P = 0.029) in vivo (Fig. 4h and Supplementary Fig. 11f–h). This evidence concerns the gene FBXO44 and neoplasm.