We also evaluated whether cisd-1 downregulation accelerates neurodegeneration by using the aggregation-prone nematode model for Parkinson’s disease (PD), UA196 [sid-1(pk3321); baIn33(pdat-1SID-1, pmyo-2mCherry);(pdat-1α-Syn, pdat-1GFP)]. The gene discussed is CISD1; the disease is Parkinson disease.