Particularly, as shown in human non-small cell carcinoma cell lines, CISD2/NAF-1 interacts with the anti-apoptotic protein B-Cell CLL/Lymphoma 2 (BCL2) and this interaction is required for the BCL2–dependent inhibition of the autophagosome initiating complex [18, 19]. Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.