Obesity-associated dysfunctional adipose tissue (AT) also secretes pro-oncogenic factors such as TNFα, IL-6, IL-1β and provides a carcinogenesis-promoting microenvironment for breast cancer development and progression; it is therefore a fundamental factor of postmenopausal breast cancer development [22]. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.