Conversely, dedifferentiated melanoma cells are not very proliferative, but particularly invasive, and show low expression of MITF and high expression of mesenchymal [9, 10], invasive [11, 12], extracellular matrix (ECM) [13], and resistance markers such as the receptor tyrosine kinase (RTK) AXL [14]. The gene discussed is AXL; the disease is melanoma.