Other genes with a notable hysterectomy risk (at p < 1e−9) were MSH6 (OR = 3.3; p = 1.9e−20) and BRCA1 (OR = 1.9; p = 9.5e−10), most likely explained by susceptibility to endometrial and ovarian cancers, respectively48,49 (Table S2). Here, BRCA1 is linked to ovarian cancer.