In summary, the combined Ki67 model incorporating clinical feature (HBV), imaging features (arterial rim enhancement on AP and enhancement pattern) and radiomics features (on T1, T1V and T1D sequences) is a potential biomarker in Ki67 prediction, and the flowchart of the combined Ki67 prediction model may be a potential tool in Ki67 stratification of ICC patients (Fig. 4). The gene discussed is MKI67; the disease is intrahepatic cholangiocarcinoma.