The adoptive transfer of a small number of NKT cells that have been ex vivo treated with HCC-derived antigens can suppress the tumor growth in HCC mice, and the effect is correlated with NKT cell number, STAT4 expression, and serum levels of IL-12, IFN-γ, and IL-4 [103]. The gene discussed is STAT4; the disease is hepatocellular carcinoma.