TM4SF5 and hepatocellular carcinoma: Furthermore, transmembrane 4 L six family member 5 (TM4SF5), which is abundant in HCC, inhibits the expression of NK cytotoxicity-stimulated membrane ligands SLAMF6, SLAMF7, and MICA/B on target HCC cells, resulting in the decreased number and functional impairment of NK cells [87].