Regarding the relationship with respective AD brain pathology, retinal S100β, not rGFAP, strongly correlated with the severity of brain Aβ plaque, NFT, and NT (Fig. 3k, l; bAβ: r = 0.83, P = 0.0003; NFT: r = 0.73, P = 0.0022; NT: r = 0.67, P = 0.0062; extended data in Suppl. This evidence concerns the gene S100B and Alzheimer disease.