The activation of apoptosis and a necrosis-enriched pathway and the upregulated DEPs Hint1 and caspase-3, along with GSDMA and GSDMD involved in pyroptotic cell death [103], which strongly correlated with retinal Aβ1-42 levels, further highlight a possible connection between Aβ and neurodegeneration in AD retinas, as we earlier demonstrated for retinal vascular amyloidosis and pericyte loss [101]. This evidence concerns the gene HINT1 and Alzheimer disease.