Genes known to be associated with FECD (COL8A2, ZEB1, SLC4A11, AGBL1, LAMC1, LOXHD1, KANK4, ATP1B1 and DMPK) [5, 55–60] were analyzed for methylation differences between FECD patients and non-FECD controls. The gene discussed is KANK4; the disease is Fuchs endothelial corneal dystrophy.