The data from the current clinical study corroborate with our preclinical studies that showed treatment of TNBC cells with tamoxifen increased interaction between ERβ and mutant p53 leading to decreased cellular proliferation.14 A diagrammatic model depicting the mechanism underlying the effect of anti-tumor effects of Tamoxifen on TNBC is shown in Fig. 3. This evidence concerns the gene TP53 and neoplasm.