Another unexpected observation of our study is that although many ITAM‐signaling receptors transmit signals through SYK, the amyloid pathology observed in SYK‐deficient mice was not more severe than that observed in TREM2‐deficient mice, suggesting that TREM2 is the predominant microglial receptor signaling through SYK, whereas other receptors may be expressed in low amounts or may not be engaged by endogenous brain ligands. The gene discussed is TREM2; the disease is amyloidosis.