For instance, a partial loss‐of‐function TREM2 missense variant, R47H, significantly increases AD risk, whereas decreased AD risk is correlated with a gain‐of‐function P522R variant of PLCG2, a phospholipase Cγ family member that is a downstream signaling effector of TREM2. The gene discussed is PLCG2; the disease is Alzheimer disease.