Genome‐wide association studies have revealed that the genetic risk factors of sporadic AD are more diversified and include, among others, genes controlling microglial activation, such as immune receptors (TREM2, MS4A4A, and CD33), signaling intermediates (PLCG2 and INPP5D) and growth factors (IL34).3 The gene discussed is TREM2; the disease is Alzheimer disease.