Among them, the key hub genes were ICAM1 (intercellular adhesion molecule 1), HRAS (Ras family small GTP binding protein H‐Ras), PTGS2 (prostaglandin‐endoperoxide synthase 2, also known as COX‐2), and FOS (FBJ osteosarcoma oncogene). Here, HRAS is linked to osteosarcoma.