CD274 and neoplasm: Among them, loss of heterozygosity (LOH) for both chromosomes 1p and 16q, which is closely associated with tumor recurrence; mutation in B7-H1 (programmed death-ligand 1 = PD-L1) as a biomarker of the immune system, which is related to an increased risk of tumor recurrence; and mutation in P53, which is involved in an increased risk of recurrence, are promising biomarkers in identifying WT [64,65,66].