In a study conducted by Lan et al., ScBEE flavonol derivative rhamnetin was identified to exhibit apoptotic activity, which is tightly associated with the overexpression of p53 and its downstream target, miR-34a, in MCF-7 cells, in addition to the downregulation of breast cancer promoter Notch1 protein [49]. The gene discussed is NOTCH1; the disease is breast cancer.