In addition, myricetin was shown to reduce BV2 microglia proinflammatory phenotype [113] and decreased the enhancement of endothelial permeability and inflammation in human brain micro-vessel endothelial cell after OGD by regulating Akt and Nrf2 pathways [114], which could potentially protect the BBB breakdown after stroke. The gene discussed is NFE2L2; the disease is Stroke.