Using this data, we found that strength training induces significant changes in the expression of 26 genes (10 upregulated: ADCY3, E2F3, JMJD1C, JUND, MLN, MYO1C, PIEZO1, PPARD, SFMBT1, ZNF462; 16 downregulated: CDKAL1, CEP192, DLEU1, GADD45G, GBF1, GLCCI1, MAML3, MMS22L, NYAP2, SDCCAG8, SWT1, TRIB1 WWP2, XPO4, ZBTB38, ZNF420) (Supplementary Table S1), which may partly explain beneficial effects of strength training in the prevention and treatment of sarcopenia. This evidence concerns the gene E2F3 and sarcopenia.