Activation of JAK2/STAT3, MAPK/ERK, and PI3k/Akt pathways have previously been linked to the binding of leptin, an adipocyte derived hormone, to Ob-R [9]; however, the effect of adipocyte coculture on uterine leiomyoma cells remained a gap in knowledge. This evidence concerns the gene STAT3 and Uterine leiomyoma.