Significant differences in S100B and high mobility group box 1 (HMGB1) concentrations were observed between patients with schizophrenia and controls [33]; in fact, an inverse correlation was found between S100B levels and the Positive and Negative Syndrome Scale (PANSS) score at discharge after acute relapses of paranoid schizophrenia [34]. This evidence concerns the gene HMGB1 and schizophrenia.