Moreover, significant gene–sleep interactions were detected between the midpoint of sleep and the TAS2R38-rs713598 (p = 0.032), FTO-rs9939609 (p = 0.037), and CLOCK-rs4580704 (p = 0.004) polymorphisms which played a role in determining obesity phenotypes. This evidence concerns the gene TAS2R38 and obesity due to melanocortin 4 receptor deficiency.