CASP3 and cancer: Cisplatin induced caspase-3 activation in both HeLa and HaCaT cells (12.7% and 16.6%, respectively) while exposure to the S. chinantlense extract induced the activation of caspase-3 in the HeLa cancer cell line but not in the HaCat cell line (30.3% and 6.3%, respectively) (Figure 6).