CASP3 and neoplasm: , that induces a rapid increase in reactive oxygen species followed by a disruption of mitochondrial membrane potential [22]; luteolin and curcumin found in celery and turmeric, respectively, which depolarize mitochondria and induce apoptosis in human tumor cells [23,24]; the crude extract of A. atroviolaceum, which induces the activation of caspase-9 and caspase-3.