Other than MPO and SLC10A2, a few genes relevant to dementia and encoding metabolic proteins are widely expressed at high levels across the panel of metabolically active tissues and at levels greater than in any brain section: SOD2 (all 12 tissues), ADH1C (all except whole blood, alcohol dehydrogenase 1C), ALDH1A2, CPT2 (carnitine palmitoyltransferase 2), MAOA (monoamine oxidase A), and PLAU (10 different tissues). The gene discussed is ADH1C; the disease is dementia.