That the NFE2L2 regulatory elements in promoter regions respond to or are activated by various flavonoids, e.g., quercetin, kaempferol, fisetin, daidzein, luteolin, and apigenin [72], provides a link between our observation and this transcriptional regulator, its target gene HMOX1, and attributes of vascular dementia. This evidence concerns the gene HMOX1 and vascular dementia.