Specifically, APOC3 (Apolipoprotein C3), APOA1(apolipoprotein A1), and MC4R (Melanocortin-4 receptor) polymorphisms increase the risk of developing MetS among patients following a Western dietary pattern; other polymorphisms in APOB (Apolipoprotein B) and TCF7L2 (transcription factor 7 like) are risk factors for MetS in the setting of high saturated fatty acid (SFA) intakes [227]. This evidence concerns the gene MC4R and metabolic syndrome.