TNF and Alzheimer disease: Interestingly, we recently showed that an easy-to-get cytokines “signature” composed of three molecules -IFNα2, IL-1α, and TNF-α- can discriminate cognitively healthy subjects from subjects affected by AD [20] IFN-α2 has a role in the amplification of the inflammatory response inducing secretion of other cytokines and its serum level are upregulated in patients with AD.