Interestingly, we recently showed that an easy-to-get cytokines “signature” composed of three molecules -IFNα2, IL-1α, and TNF-α- can discriminate cognitively healthy subjects from subjects affected by AD [20] IFN-α2 has a role in the amplification of the inflammatory response inducing secretion of other cytokines and its serum level are upregulated in patients with AD. This evidence concerns the gene IL1A and Alzheimer disease.