Akbari et al. [42] report C. spinosa fruit extract (20 mg/kg/day, for 12 weeks) to have beneficial effects against non-alcoholic steatohepatitis in Wistar rats receiving a high-fat diet, and attribute this to the upregulation of fibroblast growth factor 21 (FGF21). This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatohepatitis.