IL1B and obesity due to melanocortin 4 receptor deficiency: Excess food intake and high fat/sucrose diets, such as Western diets (WD), predispose one to obesity, characterized by an expansion of white adipose tissue (WAT), elevated free fatty acids (FFA) levels, systemic inflammation (pro-inflammatory cytokines; IL-6, TNFα, IL-1, and MCP-1), mitochondrial dysfunction, oxidative stress, insulin resistance (IR), and ectopic lipid deposition in insulin-sensitive tissues such as liver [1,2,3,4].