The differences between bone compartments, combined with the consistently higher sclerostin positivity in cortical bone tissue, indicates that both compartments are worth being included for histomorphometric evaluation to better understand the complex pathophysiology of ROD and perhaps other non-CKD related bone diseases, e.g., osteoporosis, where cortical and trabecular pathology can affect fracture risk independently [51]. The gene discussed is SOST; the disease is osteoporosis.