In contrast to the osteoblast and osteoclast, the association between the number and activity of the osteocyte with bone turnover has not been thoroughly studied, despite the fact that sclerostin, amongst several other osteocyte-derived factors performing a role in bone metabolism/mineral homeostasis, has received particular interest within the chronic kidney disease-mineral bone disorder (CKD-MBD) research community [4,6,7]. This evidence concerns the gene SOST and chronic kidney disease.