It has been reported that antioxidants can be used to inhibit vascular endothelial cell dysfunction in diabetes by inhibiting ROS production so as to inhibit lipid peroxidation and prevent oxidation of cell membrane lipids, which can reduce MDA levels and increase SOD and GPx expression by inhibiting the reduction of Nrf2 expression, further inhibiting endothelial cell damage. The gene discussed is NFE2L2; the disease is diabetes mellitus.