Indeed, some studies have associated the high levels of TMAO with high TNF-alpha, IL-6, C-reactive protein [44], pro-inflammatory cytokines, IL-1beta [96] and even as a coadjuvant of Helicobacter pylori to promote infection in the gastric epithelial cells, increasing the activity of IL-6 and chemokine ligands. This evidence concerns the gene IL6 and infection.