SIRT1 and cancer: Interestingly, different studies have highlighted that a diet rich in polyphenols has a protective function against cardiovascular, neurodegenerative, metabolic, inflammatory diseases, and cancer by increasing SIRT1 expression [65], and it has been reported that polyphenols, such as quercetin, catechins, and resveratrol, activate SIRT1 in vivo and in vitro studies [65,66,67,68].